| 摘要 |
It is intended to provide a physiologically human-like animal model, by which the onset of drug-induced long QT syndrome can be evaluated at a high reproducibility, a method of constructing the animal model, and an evaluation method with the use of the same. An animal model with induced arrhythmia which is a monkey having been subjected to atrioventricular node ablation. It is preferable that the monkey is Macca fascicularis. A method of constructing an animal model with induced arrhythmia which invovles the step of inserting an electrode catheter to the heart of a monkey and ablating an atrioventricular node with the catheter; and a method of evaluating the elongation in drug QT intervals characterized by comprising using the animal model as described above. |
