Three dimensional tissue equivalent using macromass culture

摘要

The present invention provides a three-dimensional tissue equivalent, for in-vivo and in-vitro use which is a non-contractile cellular sheet cultured over a porous scaffold using a macromass culturing technique, for example where the cellular sheet is located entirely on one side of a porous sponge. In one embodiment, the present invention provides a dermal wound dressing that comprises a high-density cellular sheet of dermal fibroblast cells.