发明名称 |
NOVEL RECOMBINANT HUMAN HEPATITIS C VIRUS-LIKE PARTICLE AND METHOD FOR PRODUCING THE SAME |
摘要 |
The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5' untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B proteins, and the 3' untranslated region of a genome RNA derived from a hepatitis C virus strain autonomously replicates, (ii) a vector expressing the Core, E1, E2, and p7 proteins derived from a hepatitis C virus strain that is the same as or different from that as defined in the above (i), culturing the cell, and recovering the produced virus-like particle, and a recombinant hepatitis C virus particle produced by this method.
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申请公布号 |
EP1930416(A1) |
申请公布日期 |
2008.06.11 |
申请号 |
EP20060810937 |
申请日期 |
2006.09.29 |
申请人 |
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES;TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH;TORAY INDUSTRIES, INC. |
发明人 |
TANABE, JUN-ICHI;SONE, SABURO;WAKITA, TAKAJI;ISHII, KOJI;SUZUKI, RYOSUKE;SUZUKI, TETSURO;MIYAMURA, TATSUO |
分类号 |
C12N7/00;C12N7/04;C12N15/09 |
主分类号 |
C12N7/00 |
代理机构 |
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