OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES

摘要

Diarylmethyl piperazine/piperidine compounds of formula (1) as shown above wherein the substituents are as defined in the description having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/ or kappa receptors. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhib it therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, and apnea, cognitive disorders, a nd gastrointestinal disorders.