| 摘要 |
A single stage flow modulator for performing comprehensive chromatography comprises a first chromatographic column, a valve fluidically coupled to at least two fluid conduits, wherein when in a first position, the valve directs a control flow to direct an output of the first chromatographic column to a first detector, and wherein when in a second position, the valve directs a control flow to direct a portion of an output of the first chromatographic column to a second chromatographic column, wherein the portion of the output of the first chromatographic column directed to the second chromatographic column is continuously modulated throughout a sample run.
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