| 发明名称 |
ANTI-VEGF ANTIBODIES |
| 摘要 |
Humanized and variant anti-VEGF antibodies and vari-ous uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced pro-liferation of endothelial cells in vitro, and inhibit tumor growth in vivo.
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| 申请公布号 |
CA2286330(C) |
申请公布日期 |
2008.06.10 |
| 申请号 |
CA19982286330 |
申请日期 |
1998.04.03 |
| 申请人 |
GENENTECH, INC. |
发明人 |
CHEN, YVONNE MAN-YEE;LOWMAN, HENRY B.;BACA, MANUEL;PRESTA, LEONARD G.;WELLS, JAMES A. |
| 分类号 |
C07K16/22;C12N15/09;A61K38/00;A61K38/17;A61K39/395;A61P25/00;A61P27/02;A61P35/00;C07K16/46;C12N5/10;C12N15/13;C12N15/66;C12P21/02 |
主分类号 |
C07K16/22 |
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