SALT-RESISTANT ANTIMICROBIAL PEPTIDES AND ANTIMICROBIAL COMPOSITION COMPRISING THEREOF

摘要

A novel antibacterial peptide is provided to show strong antibacterial activity on a wider range of microorganism species compared with a conventional antibacterial peptide and have less or no toxicity than the conventional antibacterial peptide. A peptide having the antibacterial activity in a highly concentrated salt is represented by a formula(1) of N-terminal-A P K A M X^1 X^2 X^3 X^4 X^5 L Q K K G I-C-terminal, wherein A is alanine; P is proline; K is lysine; M is methionine; X^1 is one basic amino acid; X^2 is two hydrophobic amino acids selected from the group consisting of alanine, valine and leucine; X^3 is two basic amino acids; X^4 is two hydrophobic amino acids selected from the group consisting of alanine, valine and leucine; X^5 is one basic amino acid; L is leucine; Q is glutamine; G is glycine; and I is iso-leucine. An antibacterial composition comprises the peptide as an effective ingredient.