| 摘要 |
FIELD: biotechnology. ^ SUBSTANCE: The invention proposes variants of methods for selection of compounds by their ability to interact with transmembrane proteins. An isolated cell is exposed, that is transformed by a nucleotide sequence that encodes proteins, including a transmembrane protein comprising at least one NLS and a detectable part of the molecule to be used in the proposed method. A method for detection of the ability to oligomerize proteins, such as transmembrane proteins, is proposed as well. ^ EFFECT: provides an alternative to existent methods for identification of compounds interacting with transmembrane proteins; provides with an improved method for detecting the oligomerization of transmembrane proteins. ^ 27 cl, 5 dwg, 1 tbl, 53 ex |
