发明名称 |
Methods of diagnosis and treatment by binding p75/AIRM1 |
摘要 |
p75/AIRM1 is expressed on myeloid cells at stages of differentiation and determination of its presence is useful in monitoring cellular proliferation and determining proliferative states of cells, especially myeloid cells in diseases such as chronic myeloid leukemia. Ligands such as antibody molecules, for instance the QA79 monoclonal antibody deposited under accession number ICLC No. PD99003, are useful for methods of diagnosis and treatment, e.g. by way of inhibition of cellular proliferation and induction of apoptosis in cells.
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申请公布号 |
US7384631(B2) |
申请公布日期 |
2008.06.10 |
申请号 |
US20020149593 |
申请日期 |
2002.10.02 |
申请人 |
UNIVERSITA DEGLI STUDI DI GENOVA, DIPARTIMENTO DIMEDICINA SPERIMENTALE |
发明人 |
BIASSONI ROBERTO;MORETTA ALESSANDRO;MORETTA LORENZO;MINGARI MARIA CRISTINA |
分类号 |
A61K39/395;G01N33/566;A61K45/00;A61K47/48;A61P35/02;C07K16/28;C12P21/08;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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