PHARMACEUTICAL COMPOSITION SUITABLE FOR ORAL ADMINISTRATION CONTAINING NO-RELEASING NSAID, DOSAGE FORM, PHARMACEUTICAL COMBINATION AND METHODS OF TREATMENT

摘要

The present invention claims and discloses a pharmaceutical composition suitable for oral administration, in form of an emulsion pre-concentrate, comprising: (i) one or more No-releasing NSAID(s); (ii) one or more surfactants; (iii) optionally an additional oil or semi-solid fat; said composition forming an in-situ oil-in-water emulsion upon contact with gastrointesonal fluids. The composition may optionally also comprise one or more short-chain alcohols. Also within the scope of the invention is a combination with a proton pump inhibitor. The pharmaceutical composition is useful in the treatment of pain and inflammation.