Substituted pyrrole Mannich bases for use to suppress pain and allergic reactions, method for production thereof, medicament and use

摘要

Described are substituted pyrrole Mannich bases of the general formula (I), wherein R1 = H, a C1-C10 alkyl-, aryl, a heteroaryl- or an aryl, heteroaryl- , CN, Br, Cl or OH radical bound by a C1-C6 alkylene group, R2 = CH(R4)N(R5)(R6), R3, R3', R3'' identically or individually represent H, F , Cl, Br, CF3, CN, NO2, SO2NH2, NHR7,SR8, OR9, CO(OR10), CH2CO(OR11), COR15, a C1-C10 alkyl-, aryl-, heteroaryl- aryl radical or a heteroalkyl radical bound by a C1-C6 alkylene group, R4 = an unsubstituted phenyl radical or a phenyl radical substituted at least with C1-C4 alkyl, C1-C3 alkoxy-, halogen, a method for the production of the above-mentioned compounds, medicaments containing said compounds, and the use of said compounds in the production of medicaments. Said active ingredients are particularly suitable for pain therapy, and for treating inflammatory and allergic reactions, drug or alcohol abuse, diarrhoea, gastritis, ulcers, cardiovascular diseases, urinary incontinence, depressions, states of shock, migraines, narcolepsy, overweight , asthma, glaucoma, hyperkinetic syndrome, lack of drive, bulimia, anorexia, catalepsy, anxiolysis, increasing vigilance and/or increasing libido.