| 摘要 |
PROBLEM TO BE SOLVED: To provide a medicine having an efficacy of preventing and/or treating diseases associated with a signal transmission pathway by adjusting the pathway with the elucidation of the signal transmission mechanism of the signal transmission pathway for NF-κB activation associated with IκBL. SOLUTION: This medicine capable of adjusting an alternative NF-κB activation pathway inhibitively is provided by improving the stability of the IκBL. The medicine preferably consists of a proteosome inhibitor such as MG132, etc., a deubiquitylation enzyme such as USP9X, etc., the IκBL or a gene encoding the proteosome inhibitor. The medicine is effective for the prevention and/or treatment of diseases associated with the pathway by stabilizing the IκBL in the alternative NF-κB activation pathway to exhibit the inhibitory activity. COPYRIGHT: (C)2008,JPO&INPIT
|
