COMPOSITIONS AND METHODS FOR INDUCING OR INHIBITING ACTIVITIES OF SELECTED HUMAN CELLS
摘要
<p>Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.</p>
申请公布号
WO2008066964(A2)
申请公布日期
2008.06.05
申请号
WO2007US71640
申请日期
2007.06.20
申请人
ST. JUDE CHILDREN'S RESEARCH HOSPITAL;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;POTTER, PHILIP, M.;WIERDL, MONIKA;REDINBO, MATTHEW, R.
发明人
POTTER, PHILIP, M.;WIERDL, MONIKA;REDINBO, MATTHEW, R.