| 发明名称 |
Polypeptides for Inducing a Protective Immune Response Against Staphylococcus Aureus |
| 摘要 |
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus. <tables id="TABLE-US-00001" num="00001"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="2"> <colspec colname="1" colwidth="217pt" align="left"/> <colspec colname="2" colwidth="0pt" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY><U STYLE="SINGLE">MGHHHHHHHHHHSSGHIEGRH MSLINKEILPFTAQAFDPKKDQFKEVTQE </ENTRY> <ENTRY/> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY> DLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHF </ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY> VHKAWHDHSDAISKITYTMIGDPSQTITRNDVLDEATGLAQRGTFIIDPD </ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY> GVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ </ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY> PGLDLVGKI <U STYLE="SINGLE">AEQ</ENTRY> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES>
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| 申请公布号 |
US2008131447(A1) |
申请公布日期 |
2008.06.05 |
| 申请号 |
US20060795538 |
申请日期 |
2006.01.17 |
| 申请人 |
KELLY ROSEMARIE;SCHULTZ LOREN D;MILLER MARK A;YEAGER MARK D;MCNEELEY TESSIE |
发明人 |
KELLY ROSEMARIE;SCHULTZ LOREN D.;MILLER MARK A.;YEAGER MARK D.;MCNEELEY TESSIE |
| 分类号 |
A61K39/00;A61P31/04;C07H21/00;C07K2/00;C07K7/06;C07K14/00;C07K16/00;C12N1/00;C12P21/00 |
主分类号 |
A61K39/00 |
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