发明名称 |
2- SUBSTITUTED-1ALPHA, 25-DIHYDROXY-19,26,27-TRINOR VITAMIN D ANALOGS AND USES THEREOF |
摘要 |
Compounds of Formula (I), (II) or (III) are provided where X<SUB>1</SUB>, X<SUB>2</SUB> and X<SUB>3</SUB> are independently selected from H and hydroxy protecting groups and R<SUB>1</SUB> and R<SUB>2</SUB> are independently selected from H or straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms; and R<SUB>3</SUB> is independently selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions. |
申请公布号 |
WO2008035228(A3) |
申请公布日期 |
2008.06.05 |
申请号 |
WO2007IB03919 |
申请日期 |
2007.04.06 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;DELUCA, HECTOR, F.;PLUM, LORI, A.;CLAGETT-DAME, MARGARET;GRZYWACZ, PAWEL, K. |
发明人 |
DELUCA, HECTOR, F.;PLUM, LORI, A.;CLAGETT-DAME, MARGARET;GRZYWACZ, PAWEL, K. |
分类号 |
C07C401/00;A61K31/59;A61P5/20;A61P17/00;A61P17/06;A61P19/02;A61P19/10;A61P35/00 |
主分类号 |
C07C401/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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