发明名称 |
Serotonin Reuptake Inhibitors |
摘要 |
A serotonin reuptake inhibitor which can be used in the treatment of depression and which has a decreased occurrence of unwanted side effects. The serotonin reuptake inhibitors are bi-functional organic molecules which combine serotonin transporter reuptake inhibition with serotonin (5-HT, such as 5-HT2A) receptor antagonism in one molecular entity. The serotonin-selective reuptake inhibitor (SSRI) homologue portion of the molecule shows an affinity to the serotonin reuptake transporter (SERT) and has antidepressant properties. The piperazine or piperidine portion of the molecule demonstrates an affinity to 5-HT receptors and restores the undesired side effects of SSRIs.
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申请公布号 |
US2008132514(A1) |
申请公布日期 |
2008.06.05 |
申请号 |
US20050594105 |
申请日期 |
2005.03.28 |
申请人 |
PINNEY KEVIN G;MIRANDA MARIA GRACIELA;DORSEY JAMES MICHAEL |
发明人 |
PINNEY KEVIN G.;MIRANDA MARIA GRACIELA;DORSEY JAMES MICHAEL |
分类号 |
A61K31/497;A61K31/445;A61K31/495;A61K31/496;A61K31/506;A61K47/48;A61P25/24;C07D211/30;C07D239/42;C07D295/092 |
主分类号 |
A61K31/497 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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