| 摘要 |
The present invention relates to methods for determining the potential of a subject to respond to a particular therapeutic agent, by determining the presence of one or more nucleotide or amino acid variants in the beta-tubulin gene or protein. Also provided are methods for treating subjects whose potential to respond to a therapeutic agent has been evaluated. For use in the methods of the invention, there are provided variants of the beta-tubulin gene, variants of the beta-tubulin protein, nucleic acid molecules and agents which bind to the variant beta-tubulin nucleic acid molecules and variant beta-tubulin protein, respectively, and kits comprising the same. |
