HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES

摘要

The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one radiopaque monomer according to general formula (I): wherein R is H, methyl or ethyl, and R¹ is I, Br or formula (II): wherein R² is O, NH, 0-[CH₂-CH₂-O]_P-C(O)-, O- [CH₂] _m-O-C(O)-, O-[CH₂]_p-, NH-[CH₂-CH₂-O]_p-C(O)-, NH-[CH₂]_m-O-C(O)- or NH-[CH₂]_p- wherein m>l and p=l, R³ is I or Br and n is 1, 2 or 3, the iodine and/or bromine content being at least 5 wt.% based on the dry weight of the particle, the said particles having an average particle diameter of at least 10 µm and being able to imbibe water up to a volume increase of the particle of at least 10 %.