CARBOXYMETHYL CELLULOSE-STABILISED TISSUE FILLER AND ITS PREPARATION AND USE

摘要

The invention pertains to a tissue filler suspension containing tissue filler material, wherein the suspension further contains carboxymethyl cellulose (CMC) and is free from glycerine and surfactant, preferably free from any foreign body materials other than said CMC. The suspension finds use in soft, hard and connective tissue augmentation; for that purpose ceramic particles, e.g. comprising calcium phosphate, and/or biodegradable polymers such as polylactic acid or PEG-BPT copolymer, may be applied. The CMC is characterized in that a 1.0 wt% concentration thereof in water would exhibit a viscosity of at least 9,000 mPas as determined by a Brookfield, LVT, 30 rpm, spindle 4, at a temperature of 25 °C. A suitable CMC is that described in WO- A-99/20657.