发明名称 |
SEQUENCE PATTERN DESCRIPTORS FOR TRANSMEMBRANE STRUCTURAL DETAILS |
摘要 |
The relationship between an amino acid sequence of a protein and its three-dimensional structure is at the very core of structural biology and bioinformatics. The occurrence and conservation of non-canonical conformations is a "local" phenomenon, i.e., non-canonical conformations are encoded intra-helically by short peptide sequences (heptapeptides at most). Effective descriptors can be formed for these short sequences employing training sets. Multiple, distinct patterns are created representing these sequences. A composite descriptor is formed by selecting from among the patterns discovered. The composite descriptor has a high level of sensitivity and specificity while, at the same time, a boosted signal-to-noise ratio.
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申请公布号 |
US2008133142(A1) |
申请公布日期 |
2008.06.05 |
申请号 |
US20070852671 |
申请日期 |
2007.09.10 |
申请人 |
INTERNATIONAL BUSINESS MACHINES CORPORATION |
发明人 |
RIGOUTSOS ISIDORE;RIEK PETER;GRAHAM ROBERT M.;NOVOTNY JIRI |
分类号 |
G01N33/68;C12Q1/68;G01N33/48;G01N33/50;G01N33/53;G06F19/00 |
主分类号 |
G01N33/68 |
代理机构 |
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主权项 |
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地址 |
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