NUCLEASE-RESISTANT RNA APTAMER INHIBITING REPLICATION OF HEPATITIS C VIRUS REPLICON

摘要

Disclosed a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5 B and inhibiting the proliferation of the HCV replicon, and is composed of a t least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2' -hydroxy of both U (uracil) a nd C (cytosine) bases, and SEQ ID NO. 4, which is tagged with a cholesteryl group at a 5' end and with idT at a 3' end. The RNA aptamer is useful in the diagnosis and treatment of HCV infection.