| 摘要 |
An aryl compound as a peroxisome poliferator activated receptor(PPAR) ligand is provided to realize a high selective activation degree to PPAR and to give a pharmaceutical composition, cosmetic composition, anabolic agent, memory enhancing agent, agent for treating dementia or Parkinson's disease, functional food and animal feed composition. An aryl compound as a PPAR ligand is a compound represented by the following formula (I), or hydrate, solvate, stereoisomer or pharmaceutically acceptable salt thereof. In formula (I), A is S or Se; B is H or the formula (a); R1 is an aryl group selected from the formula (b); R2 is H, C1-C8 alkyl or the formula (c); R3 is H, a C1-C8 alkyl or halogen; each of R4 and R5 is H or a C1-C8 alkyl; R6 is H, a C1-C8 alkyl, C2-C7 alkenyl, alkali metal or alkaline earth metal; each of R11 and R12 is H, a C1-C8 alkyl or halogen; R21 is H, a halogen. C1-C7 alkyl, heterocyclic group or C1-C7 alkoxy group; each of m and n is an integer of 1-4; p is an integer of 1-5; q is an integer of 1-4; r is an integer of 1-3; and s is an integer of 1-5, wherein the alkyl and alkoxy of R2, R3, R4, R5, R6, R11, R12 and R21 are optionally substituted with at least one halogen or C1-C5 alkylamine, with the proviso that a compound wherein R2 is H and A is S is excluded. |
