发明名称 |
Fc Receptor Homolog Antibodies And Uses Thereof |
摘要 |
Provided herein are antibodies having the same epitope specificity as an antibody produced by the hybridoma cell line deposited with the American Type Culture Collection as hybridoma 4-2A6, 1-5A3, or 1-3B4. Further provided herein are methods of identifying and selecting cells that express FcRH1 or FcRH4. Methods of diagnosing and treating a subject with a malignancy of a hematopoietic cell lineage or an autoimmune disease and methods of modulating a humoral immune response in a subject are also provided herein. Further provided herein are polypeptides comprising one or more complementary determining regions of the disclosed antibodies and nucleic acids that encode the disclosed polypeptides.
|
申请公布号 |
US2008131433(A1) |
申请公布日期 |
2008.06.05 |
申请号 |
US20050576022 |
申请日期 |
2005.09.27 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
DAVIS RANDALL S.;COOPER MAX D.;LEU CHUEN-MIIN;EHRHARDT GOETZ R. |
分类号 |
A61K39/395;A61P37/00;C07K16/18;C12N5/06;G01N33/564;G01N33/567;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|