BONE DEFECT FILLER, RELEASE-CONTROLLED CARRIER, AND THEIR PRODUCTION METHODS

摘要

[PROBLEMS] To provide a bone defect filler having controlled release of a medicinal agent such as a growth factor, and to provide a release-controlled carrier having controlled release of a medicinal agent. [MEANS FOR SOLVING PROBLEMS] It is found that, in a bone defect filler having a medicinal agent contained therein, the adsorption of the medicinal agent to the bone defect filler can be controlled by inactivating a functional group in the bone defect filler which can strongly bind to the medicinal agent with a blocking agent, and therefore it becomes possible to control the release of a growth factor or the like from the bone defect filler. Specifically disclosed are: a bone defect filler or a release-controlled carrier which comprises a calcium-containing substance such as hydroxyapatite, carbonate apatite, fluorapatite, chlorapatite, ß-TCP and a-TCP, a blocking agent for the calcium-containing substance such as serine and dextran, and a medicinal agent; and others.