| 摘要 |
The invention is an improved method for the preparation of tertiary phosphin es by way of cross-coupling of aryl, alkenyl, cycloalkenyl or aralkyl halides or aryl, alkenyl, cycloalkenyl or aralkyl sulfonate ester s with chlorophosphines in the presence of a catalyst and a reductant. In general reaction scheme (I), R1 is aryl, alkenyl, cycloalkenyl or aralkyl , any of which may be substituted by one or more of the following: alkyl, aryl, aralkyl, alkoxy, alkanoyl, chloro, fluoro, alkoxycarbonyl, cyan o, trifluoromethyl, cycloalkyl, or CONR4R5 wherein R4 and R5 are independently hydrogen, alkyl, aryl or aralkyl; R2 and R3 are independently aryl, alkyl, aralkyl, any of which may be substituted by one or more of the following: alkyl, aryl, arylkyl, alkoxy, alkanoyl, chloro , fluoro, alkoxycarbonyl, cyano, trifluoromethyl, cycloalkyl or CONR4R5 wherein R4 and R5 are independently hydrogen, alkyl, aryl or aralkyl ; and n is 2 where R1 is a difunctional moiety and 1 for any other R1; and X isC1, Br, I, or OSO2Y; wherein Y is alkyl, trihalomethyl , phenyl, halophenyl, or alkylphenyl.
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