摘要 |
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant canary poxvirus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
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申请人 |
CONNAUGHT TECHNOLOGY CORPORATION |
发明人 |
JOHNSON, GERARD P.;GETTIG, RUSSELL ROBERT;PAOLETTI, ENZO;LIMBACH, KEITH J.;PERKUS, MARION E.;TAYLOR, JILL;TARTAGLIA, JAMES;PINCUS, STEVEN E.;AUDONNET, JEAN-CHRISTOPHE F.;NORTON, ELIZABETH K.;DE TAISNE, CHARLES;COX, WILLIAM I.;RIVIERE, MICHEL |