发明名称 |
Treatment of cancer by reduction of intracellular energy and pyrimidines |
摘要 |
This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at least 15% of normal in cancer cells, a pyrimidine antagonist, and an anticancer agent to which the treated cancer is sensitive. This invention also provides a composition comprising a combination of ATP-depleting agents at concentrations which deplete the ATP level to at least 15% of normal in cancer cells, a pyrimidine antagonist, and an anticancer agent to which the treated cancer is sensitive. Finally this invention provides a pharmaceutical composition comprising the above composition or a combination thereof and a pharmaceutically acceptable carrier.
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申请公布号 |
US7381713(B2) |
申请公布日期 |
2008.06.03 |
申请号 |
US20020172346 |
申请日期 |
2002.06.13 |
申请人 |
SIOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
MARTIN DANIEL S.;BERTINO JOSEPH R.;KOUTCHER JASON |
分类号 |
A61K31/70;A61K31/19;A61K31/21;A61K31/26;A61K31/455;A61K31/505;A61K31/51;A61K31/57;A61K31/573;A61K31/66;A61K31/7072;A61K31/7076;A61K38/18;A61K45/06 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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