Histone deacetylase inhibitors

摘要

Compounds that may be used to inhibit histone deacetylase having the formula <?in-line-formulae description="In-line Formulae" end="lead"?>Z-Q-L-M or Z-L-M<?in-line-formulae description="In-line Formulae" end="tail"?> wherein M is a substituent capable of complexing with a deacetylase catalytic site and/or a metal ion; L is a substituent providing between 0-10 atoms separation between the M substituent and the remainder of the compound; and Z and Q are as defined herein.