发明名称 |
Humanized antibodies against CD3 |
摘要 |
The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific components of the bispecific antibodies, humanized versions thereof, and humanized bispecific antibodies. The invention further provides therapeutic and diagnostic methods employing these antibodies.
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申请公布号 |
US7381803(B1) |
申请公布日期 |
2008.06.03 |
申请号 |
US20000618380 |
申请日期 |
2000.07.18 |
申请人 |
PDL BIOPHARMA, INC.;IOWA IMMUNOTHERAPY INVESTIGATORS |
发明人 |
WEINER GEORGE;GINGRICH ROGER;LINK BRIAN K.;TSO J. YUN |
分类号 |
C07K16/30;A61K38/00;C07K16/28 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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