DRUG DISCOVERY FOR CANCER

摘要

The present invention relates to a method for identifying compounds which alter the activity of gamma- secretase, comprising providing a collection of compounds; contacting the compounds of the collection with a cell line or organism expressing gamma-secretase; measuring the gamma-secretase activity in the cell line or organism before and after the contact with the compound; and identifying the compounds in the collection that modulate the gamma-secretase activity of the cell line or organism as leads for the development of compounds for use in the treatment of cancer. The invention further relates to the compound thus identified and the use thereof in therapy.