NOVEL PHYSIOLOGICAL SUBSTANCE NESFATIN, SUBSTANCE RELEVANT THERETO, AND USE OF THE SUBSTANCES

摘要

A novel method for obtaining a factor involved in the control of food intake and/or body weight; a gene produced by the method, a polypeptide encoded by the gene or a novel peptide produced based on the information on the polypeptide encoded by the gene for use as a means for the treatment/control/diagnosis of a disease involving the eating disorder and/or body weight control; and a substance capable of inhibiting the action of the gene or polypeptide for use as a means for the treatment/control/diagnosis of a disease involving the control of food intake and/or body weight. A gene or polypeptide involved in the suppression of food intake and/or decrease in body weight can be produced by using a thiazolidione having a PPAR?-agonistic activity. NESFATIN or the like produced by the method can be used as a means for the treatment/control/diagnosis of a disease involving the eating disorder and/or body weight control.