发明名称 |
Constructs and methods for expression of recombinant proteins in methylotrophic yeast cells |
摘要 |
The current invention relates to vectors and methods for efficient expression of proteins in methylotrophic yeast cells. More particularly said vectors comprise the coding sequence for a lysozyme signal peptide or a functional equivalent thereof joined to a protein. Said lysozyme signal peptide is efficiently removed when the protein comprising said lysozyme signal peptide joined to a protein is expressed in methylotrophic yeast cells, such as Hansenula polymorpha and Pichia pastoris.
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申请公布号 |
US2008124763(A1) |
申请公布日期 |
2008.05.29 |
申请号 |
US20070902807 |
申请日期 |
2007.09.25 |
申请人 |
SABLON ERWIN;VAN BROEKHOVEN ANNIE;BOSMAN FONS;DEPLA ERIK;DESCHAMPS GEERT |
发明人 |
SABLON ERWIN;VAN BROEKHOVEN ANNIE;BOSMAN FONS;DEPLA ERIK;DESCHAMPS GEERT |
分类号 |
C12P21/00;A61K39/00;C07K14/18;C12N1/19;C12N15/52;C12N15/74 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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