发明名称 |
CIRCULATING VE-CADHERIN AS A PREDICTIVE MARKER OF SENSITIVITY OR RESISTANCE TO ANTI-TUMORAL TREATMENT, AND IMPROVED METHOD FOR THE DETECTION OF SOLUBLE PROTEINS. |
摘要 |
The application relates to improved means for the detection of soluble protein(s), such as soluble angiogenesis-related protein(s), more particularly circulating VE-cadherin. These means notably comprise the dilution of the fluid sample (e.g., serum or plasma sample), before submitting it to protein detection. Said dilution is advantageously diluted in a surfactant-containing solution. The improved means of the invention enabled to determine that circulating VE-cadherin is a reliable prognostic marker of the sensitivity or resistance to anti-tumoral treatment. It is believed that prior art sVE-cadherin detection means did not enable such determination. |
申请公布号 |
WO2008062314(A2) |
申请公布日期 |
2008.05.29 |
申请号 |
WO2007IB04252 |
申请日期 |
2007.11.23 |
申请人 |
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE JOSEPH FOURIER;VILGRAIN, ISABELLE;PELLETIER, LAURENT;CAND, FRANCINE |
发明人 |
VILGRAIN, ISABELLE;PELLETIER, LAURENT;CAND, FRANCINE |
分类号 |
G01N33/574;G01N33/53 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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