发明名称 |
IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES |
摘要 |
The present invention relates to novel immunogenic compositions (e.g., vaccines), the production of such immunogenic compositions and methods of using such compositions. More specially, this invention provides unique immunogenic molecules comprising an HMGB1 polypeptide (e.g., an HMGB1 B-box polypeptide) and an antigen. Even more specificially, this invention provides novel fusion proteins comprising an isolated HMGB1 polypeptide and an antigen such that administration of these fusion proteins provides the two signals required for native T - cell activation. |
申请公布号 |
WO2006083301(A3) |
申请公布日期 |
2008.05.29 |
申请号 |
WO2005US21691 |
申请日期 |
2005.06.16 |
申请人 |
MEDIMMUNE, INC.;THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH;MESSMER, DAVORKA;TRACEY, KEVIN;KIENER, PETER;ALBAN, SCOTT |
发明人 |
MESSMER, DAVORKA;TRACEY, KEVIN;KIENER, PETER;ALBAN, SCOTT |
分类号 |
C12P21/06;C07K14/00;C07K16/00;C12N15/74 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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