CHEMICAL COMPOUNDS

摘要

Phosphoramidate derivatives of nucleoside compounds derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C virus. The glycoside moiety of the nucleoside compound is suitably substituted at the ß-2' position with methyl and the phosphoramidate group suitably comprises 1-naphthyl linked by -O- to the P atom.