发明名称 |
SELECTIVE INHIBITION OF MATRIX METALLOPROTEINASES |
摘要 |
Synthetic triple-helical peptides (THPs) are used for the design and synthesis of triple-helical transition state analog inhibitors. These inhibitors feature a phosphonate ester or phosphinic moiety in place of the scissle bond. These groups inhibit MMPs, and methods been developed for their convenient incorporation within a peptide sequence by solid-phase methods.
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申请公布号 |
US2008125354(A1) |
申请公布日期 |
2008.05.29 |
申请号 |
US20060562295 |
申请日期 |
2006.11.21 |
申请人 |
FLORIDA ATLANTIC UNIVERSITY;BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE |
发明人 |
FIELDS GREGG B.;HAMMER ROBERT |
分类号 |
A61K38/02;A61K31/662;A61K31/664;A61P21/00;A61P43/00 |
主分类号 |
A61K38/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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