发明名称 |
ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-BRIDGED POLYMERIC MICELLE |
摘要 |
Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and isRNA. |
申请公布号 |
WO2008062909(A1) |
申请公布日期 |
2008.05.29 |
申请号 |
WO2007JP73130 |
申请日期 |
2007.11.22 |
申请人 |
THE UNIVERSITY OF TOKYO;KATAOKA, KAZUNORI;NISHIYAMA, NOBUHIRO;MATSUMOTO, SATORU |
发明人 |
KATAOKA, KAZUNORI;NISHIYAMA, NOBUHIRO;MATSUMOTO, SATORU |
分类号 |
A61K48/00;A61K31/7088;A61K47/34;A61K47/42;A61P35/00 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|