发明名称 |
INTRAVENOUS IMMUNOGLOBULIN COMPOSITION |
摘要 |
A method for preparing a concentrated, immunoglobulin composition for treating subjects vaccinated against or infected with a pathogenic microorganism, comprising: (a) selecting a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism; (b) determining the level of specific antibodies immunoreactive with the pathogenic microorganism in a blood or blood component of the individuals to identify very high titre individuals having a very high titre of the specific antibodies; (c) combining blood or blood components comprising immunoglobulins from the very high titre individuals; and (d) purifying and/or concentrating the product of step (c), thereby obtaining a concentrated immunoglobulin composition. Also disclosed is a concentrated immunoglobulin composition comprising specific antibodies immunoreactive with a pathogenic microorganism, characterized in that the titre of specific antibodies of the composition is at least 5 times higher than the average titre of specific antibodies of a population of individuals previously vaccinated against one or more antigens associated with the pathogenic microorganism. The composition has a relatively high protein concentration and a low percentage of protein aggregates, and is therefore suitable for both iv and im administration. In a preferred embodiment, the pathogenic microorganism is smallpox virus or vaccinia virus. |
申请公布号 |
EP1924602(A1) |
申请公布日期 |
2008.05.28 |
申请号 |
EP20060756239 |
申请日期 |
2006.07.06 |
申请人 |
OMRIX BIOPHARMACEUTICALS LTD. |
发明人 |
NUR, ISRAEL;BAR, LILIANA;LAUB, ORGAD |
分类号 |
C07K16/08;A61K39/395;A61P31/12 |
主分类号 |
C07K16/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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