发明名称 |
Crystalline composition containing escitalopram oxalate |
摘要 |
The present invention discloses crystalline particles of escitalopram oxalate which either have a broad particle size distribution or comprise at least 0.01 % (w/w) of Z-4-(4-dimethylamino-1-(4-fluorophenyl)-but-1- enyl)-3-hydroxymethyl-benzonitrile, said particles being suitable for use in direct compression. Furthermore, the invention discloses a novel pharmaceutical unit dosage form containing such crystalline particles of escitalopram oxalate as well as methods for manufacture of such crystalline particles of escitalopram oxalate. Finally, the invention provides a method for reduction of the amount of hydroxyl containing impurities in a solution of citalopram or escitalopram. |
申请公布号 |
ZA200607382(B) |
申请公布日期 |
2008.05.28 |
申请号 |
ZA20060007382 |
申请日期 |
2005.02.21 |
申请人 |
H. LUNDBECK A/S. |
发明人 |
BOJSTRUP, KIM;HUMBLE, RIKKE EVA;LILJEGREN, KEN;CHRISTENSEN TROELS VOLSGAARD |
分类号 |
A61K;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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