发明名称 Ester derivatives of rhein and their therapeutic use
摘要 Compounds that may have anti-inflammatory activity are of general formula (I); wherein X1, is H or COR1, and X2 is H or COR2 but X1, and X2 are not both H; R1 and R2 are the same or different and are each C1-4 alkyl substituted with R3, or a four to seven-membered ring which can be optionally substituted with R8 and can contain one or more additional heteroatoms selected from O, S(O)n and NR9; is R3 is F, CF3, OR4, NR5R6 O, S(O)n R7; R4, R5 and R6 are the same or different and are each H or C1-4 alkyl optionally substituted with R3, or NR5R6 is a C4-6 heterocycloalkyl ring containing one or more heteroatoms selected from O, NR8 and S(O)n; each n is 0-2; R7 is C1-4 alkyl; R8 is as defined for R3 or C1-4 alkyl optionally substituted with R3 or halogen; and R9 is H or C1-4 alkyl; or a salt, solvate or hydrate thereof.
申请公布号 ZA200607386(B) 申请公布日期 2008.05.28
申请号 ZA20060007386 申请日期 2005.03.04
申请人 SOSEI R&D LTD. 发明人 BAXTER, ANDREW DOUGLAS;WALMSLEY, ANDREA
分类号 A61K;C07C;C07C66/02;C07D;C07D307/12;C07D309/10 主分类号 A61K
代理机构 代理人
主权项
地址