发明名称 |
2, 4, 6-Trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer |
摘要 |
The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R<SUP>1</SUP>, R<SUP>2</SUP>, q, R<SUP>3</SUP>, r, R<SUP>4</SUP>, X<SUP>1 </SUP>and Q<SUP>1 </SUP>have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the production of an anti-proliferative effect in a warm-blooded animal such as man. |
申请公布号 |
ZA200700054(B) |
申请公布日期 |
2008.05.28 |
申请号 |
ZA20070000054 |
申请日期 |
2007.01.02 |
申请人 |
ASTRAZENECA AB. |
发明人 |
BAILEY, JOHN PETER;PASS, MARTIN;GILES, MICHAEL BRIAN |
分类号 |
A61K;A61P;C07D;C07D239/42;C07D401/12;C07D403/12;C07D409/12;C07D417/12 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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