发明名称 |
Use of squalenic acid for the formulation of an active principle in nanoparticle state |
摘要 |
<p>2',2'-Difluoro-2'-deoxycytidine derivatives (I) are new. 2',2'-Difluoro-2'-deoxycytidine derivatives of formula (I) are new. R 1-R 3 each : hydrogen or hydrocarbyl acyl of at least 18C with a conformation that imparts the capacity for (I) to adapt a compacted form in polar solvent, provided at least one is other than hydrogen. Independent claims are also included for the following: (1) nanoparticles (NP) of (I); (2) method for preparing NP; and (3) use of squalenic acid (II), or its derivatives, for formulating at least one polar active agent of molecular weight over 100 as nanoparticles. [Image] ACTIVITY : Cytostatic; Virucide. MECHANISM OF ACTION : (I) is converted intracellularly into its triphosphate and when this is incorporated into replicating DNA, elongation is stopped, resulting in cell death.</p> |
申请公布号 |
EP1925624(A1) |
申请公布日期 |
2008.05.28 |
申请号 |
EP20080100379 |
申请日期 |
2005.06.23 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE PARIS-SUD (PARIS 11);ROCCO, FLAVIO |
发明人 |
ROSILIO, VERONIQUE;RENOIR, JACK-MICHEL;COUVREUR, PATRICK;ROCCO, FLAVIO;CATTEL, LUIGI;STELLA, BARBARA |
分类号 |
C07H19/073;A61K31/706 |
主分类号 |
C07H19/073 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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