发明名称 |
Stabilised mRNA tumour vaccins |
摘要 |
Pharmaceutical composition (A) contains at least one mRNA (I), including at least one region that encodes a tumor antigen (Ag), and an aqueous solvent. An independent claim is also included for a method of preparing (A) that comprises: (a) preparing a (partial) cDNA library from tumor tissue; (b) preparing a matrix for in vitro transcription of RNA from the (partial) library; and (c) in vitro transcription of the matrix. ACTIVITY : Cytostatic. Female mice that expressed the rat Her-2/neu oncogene were immunized with mRNA that encoded a truncated form of the Her-2/neu protein (lacking the cytoplasmic regions). Four of ten treated animals were still free of tumors after 9 months; untreated controls had all developed palpable breast tumors after about 20 weeks. MECHANISM OF ACTION : Vaccine. |
申请公布号 |
EP1925317(A1) |
申请公布日期 |
2008.05.28 |
申请号 |
EP20070013494 |
申请日期 |
2002.12.19 |
申请人 |
CUREVAC GMBH |
发明人 |
HOERR, INGMAR, DR.;VON DER MUELBE, FLORIAN;PASCOLO, STEVE, DR. |
分类号 |
A61K39/00;A61K38/19;A61P35/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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