发明名称 |
NF-kappaB oligonucleotide decoy molecules |
摘要 |
The present invention concerns double-stranded NF-kappaB decoy oligodeoxynucleotide (NF-kappaB dsODN) molecules that contain a core sequence capable of specific binding to an NF-kappaB transcription factor. In a particular aspect, the invention concerns NF-kappaB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-kappaB decoy molecules with improved binding affinity to p65.
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申请公布号 |
US7378509(B2) |
申请公布日期 |
2008.05.27 |
申请号 |
US20040004512 |
申请日期 |
2004.12.02 |
申请人 |
ANESIVA, INC. |
发明人 |
MCEVOY LESLIE M.;PARHAM CHRISTI;ZHANG JIE;EHRHARDT ROLF |
分类号 |
C07H21/04;A61K48/00;C12N15/113;C12N15/115 |
主分类号 |
C07H21/04 |
代理机构 |
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地址 |
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