| 摘要 |
A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: R1 represents a hydrogen atom or a C<SUB>1-6 </SUB>alkyl group which may be substituted by a C<SUB>6,10 </SUB>aryl group; R2 represents a C<SUB>1-10 </SUB>alkyl group which may be substituted, a C<SUB>2-6 </SUB>alkenyl group which may be substituted, a C<SUB>3-6 </SUB>alkynyl group which may be substituted, a C<SUB>3-6 </SUB>cycloalkyl group which may be substituted, or a C<SUB>6-10 </SUB>ARYL group which may be substituted; or R1 and R2 form together a C<SUB>2-6 </SUB>alkylene group which may be substituted; or R1 and R2 form together a chain of formula -(CH<SUB>2</SUB>)<SUB>2</SUB>-X-(CH<SUB>2</SUB>)<SUB>2</SUB>- or -(CH<SUB>2</SUB>)<SUB>2</SUB>-X-(CH<SUB>2</SUB>)<SUB>3</SUB>- where X represents a oxygen atom, a sulfur atom, or a nitrogen atom which may be substituted; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C<SUB>1-4 </SUB>alkyl group, C<SUB>1-4 </SUB>alkoxy group or halogen atom; and R4 represents a C<SUB>1-10 </SUB>alkyl group optionally substituted by a hydroxyl group, amino, C<SUB>1-6 </SUB>monoalkylamino group, C<SUB>2-12 </SUB>dialkylamino group or C<SUB>6,10 </SUB>aryl group which may be substituted. And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3beta such as Alzheimer's disease.
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