NERVE ELONGATION PROMOTER AND ELONGATION INHIBITOR

摘要

It is intended to contribute to the elucidation of the mechanism of postzoster neuralgia and to provide means for promoting the regeneration of damaged nerve. Further, it is intended to provide means which is effective in the prevention or treatment of a disorder caused by neuronal cell death accompanying postzoster neuralgia, chronic pain, postherpetic neuralgia, apoplexy, a degenerative disease or the like, or any of the above diseases, and has fewer side effects. A neurite elongation promoter comprising an antibody that recognizes a varicella-zoster virus immediate-early protein and crossreacts with a brain-derived neurotrophic factor as an active ingredient; a preventive or therapeutic agent for a neurogenic disease comprising the antibody as an active ingredient; a neurite elongation inhibitor comprising an inhibitory antibody that recognizes a varicella-zoster virus immediate-early protein and inhibits a brain-derived neurotrophic factor as an active ingredient; and a preventive or therapeutic agent for a disease accompanied by neural hypersensitivity caused by a condition selected from the group consisting of postzoster neuralgia, chronic pain, experience-dependent social aversion and stress, comprising the inhibitory antibody as an active ingredient.