| 发明名称 |
METHODS AND COMPOSITIONS FOR MODIFICATION OF THE HUMAN GLUCOCORTICOID RECEPTOR LOCUS |
| 摘要 |
Disclosed herein are methods and compositions for inactivation of the hum an glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA enc oding the GR. Such methods and compositions are useful, for example, in ther apeutic applications which require retention of immune function during gluco corticoid treatment. |
| 申请公布号 |
CA2667414(A1) |
申请公布日期 |
2008.05.22 |
| 申请号 |
CA20072667414 |
申请日期 |
2007.11.13 |
| 申请人 |
CITY OF HOPE;SANGAMO BIOSCIENCES, INC. |
发明人 |
GREGORY, PHILIP D.;ANDO, DALE;HOLMES, MICHAEL C.;JENSEN, MICHAEL;REIK, ANDREAS |
| 分类号 |
C07K19/00;A61K38/16;A61K38/46;A61K48/00;C07K14/72;C12N9/22;C12N15/00;C12N15/62;C12N15/63;C12N15/86;C12Q1/68 |
主分类号 |
C07K19/00 |
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