| 发明名称 |
Human endothelin receptor |
| 摘要 |
DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)<SUP>+</SUP>RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 is an ET<SUB>A</SUB>-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ET<SUB>B</SUB>-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.
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| 申请公布号 |
US2008119638(A1) |
申请公布日期 |
2008.05.22 |
| 申请号 |
US20040934973 |
申请日期 |
2004.09.03 |
| 申请人 |
IMURA HIROO;NAKAO KAZUWA;NAKANISHI SHIGETADA |
发明人 |
IMURA HIROO;NAKAO KAZUWA;NAKANISHI SHIGETADA |
| 分类号 |
C07K1/00;C07K14/705;C07K14/00;C07K14/72;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12R1/91 |
主分类号 |
C07K1/00 |
| 代理机构 |
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