QUINOLINE METHANOL COMPOUNDS FOR THE TREATMENT AND PREVENTION OF PARASITIC INFECTIONS
摘要
Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and used for malaria prophylaxis. However it is associated with neurological effects. The present invention is directed to providing new and novel quinoline analogs that are less neurotoxic than mefloquine without compromising efficacy. The present invention is also directed to the prevention and treatment of other microbial, parasitic, protozoan, bacterial and fungal diseases.
申请公布号
WO2008060269(A2)
申请公布日期
2008.05.22
申请号
WO2006US42047
申请日期
2006.10.27
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY;DOW, GEOFFREY, S.;SMITH, KIRSTEN;HEADY, TIFFANY, N.
发明人
DOW, GEOFFREY, S.;SMITH, KIRSTEN;HEADY, TIFFANY, N.
