MARKER SPECIFIC TO AN OXIDATION DEGRADATION OF TISSUES CONTAINING TYPE III COLLAGEN, MEANS AND METHODS, AND KITS FOR THE TRACKING DIAGNOSIS OR PROGNOSIS OF PATHOLOGIES TARGETED BY SAID MARKER

摘要

The invention relates to a new peptide marker specific to an oxidation degradation of tissues containing type II collagen, preferably the nitrosylation of type III collagen. The main purpose of the invention is to provide an early or pre-symptomatic specific marker for diseases involving an oxidation degradation of tissues containing type II collagen, in particular inflammatory conditions such as osteoarticular diseases. The marker of the invention is characterised in that it comprises at least a peptide sequence of 5 to 25 amino acids, preferably 5 to 20 AA, and more preferably 4 to 15 AA including the subsequence QYDSYD in which at least one Y is nitrosylated and in which Q corresponds both to glutamine and pyroglutamic acid. The invention also relates to means and methods as well as kits for the tracking diagnosis or prognosis of pathologies targeted by said marker, in particular inflammatory conditions such as osteoarticular diseases.